Master of Science in Pharmacy (MScPharm) Clinical Pharmacy

Overview

The MScPharm Program is consistent with university‟s mission and aims to provide students with the knowledge and skills that will enhance their competency as health care professionals.
The program also promotes the mission of COPHS in raising awareness about current health issues and how to address them both at national and regional levels. In addition, it contributes to improvement of the pharmacy profession in the United Arab Emirates and the Arabian Gulf region by introducing new practices in pharmaceutical sciences.

MScPharm Goals

The MScPharm program is designed to equip pharmacists with the fundamental knowledge and skills that will give them the expertise to promote the pharmacy profession in the fields of clinical pharmacy and pharmaceutical technology. .

Program Objectives

The MScPharm Program is designed for graduates holding a degree in pharmacy or in a related health science.
The objectives of the program are:

  • acquire in-depth knowledge in applied pharmaceutical sciences.
  • advance skills in drug design, development and control.
  • increase knowledge of pharmacy practice and health care policies.
  • improve life-long learning skills, critical thinking and problem solving abilities.
  • acquire the ability to conduct applied research in the field of health sciences.

Program Learning Outcomes

Learning outcomes of the MScPharm program are intended to improve knowledge, skill and career of the graduates.
Upon completion of the program, graduates will be able to:

  • apply their in-depth knowledge of the field to promote pharmacy practice.
  • demonstrate that they have gained practical skills in instrumental analysis, clinical testing and quality control of drugs.
  • evaluate therapeutic management of diseases based on knowledge of drug design, pharmacokinetics and pharmacotherapy.
  • demonstrate their ability to solve problems and suggest solutions in health issues related to the local community.
  • demonstrate their ability to conduct healthcare related research.
  • demonstrate that they have gained skills in communication with other health providers and beneficiaries.

Degree Completion Requirements

The MScPharm Program consists of 2 concentration areas (clinical pharmacy and pharmaceutical technology) taught in 36 credit hours spread over three semesters (full-time students) to five semesters (part-time students).

These include 15 credit hours core curriculum courses (11 credit hours of college requirements and 4 credit hours of university requirements), 21 credit hours of concentration courses, which includes 6 credit hours for the research thesis.

Admission Requirements

Admission to the MScPharm Program is open for graduates of accredited Bachelor of Pharmacy
programs (B.Pharm.)

Admission Requirements:

Admission to the MScPharm program is open for graduates of accredited Bachelor of Pharmacy programs (BPharm).

Required Documents:

  • An officially attested BPharm degree from an accredited institution.
  • Original or officially attested copies of English Proficiency score test such as: TOEFL (550), IELTS (6).
  • At least two letters of academic references submitted in a sealed envelope.
  • Six recent passport size photographs.
  • Copy of your passport.
  • Medical fitness, certificate from the University doctor.
  • Proof of payment of a non-refundable application fee as determined by the finance office.
  • Other documents which the program may require.

Admission General Requirements:

ii-a: Full Admission:

For full admission to the MScPharm program, an applicant must:

  1. Hold a BPharm degree from an accredited institution. A Higher Diploma is not equivalent to a baccalaureate degree and does not qualify an applicant for admission to Master’s programs.
  1. Have attained a minimum cumulative grade point average of 3.0 on a 4.0 scale or its equivalent.
  2. Have attained a minimum TOEFL score of 550 (213 CBT, 79 – 80 IBT) or its equivalent in a standardized English Language test such as a 6 IELTS.
  1. For programs taught in English, a minimum TOEFL score of 550 on the Paper-Based, 213 on the Computer-Based, or 79 on the Internet-Based test, or its equivalent in a standardized English language test, such as 6.0 IELTS or another standardized, internationally recognized test approved by the Commission.
  1. Agree to be a full-time student for two years. However, part-time students can be accepted after consideration of the student’s background, present position and availability for study and research.

 

ii-b:  Conditional admission requirements for Master’s level programs

(1)   Conditional admission due to non fulfillment of English proiciency requirement: 

A student with a recognized baccalaureate degree and a TOEFL score of 530 (197 CBT, 71 iBT) or its equivalent on another standardized test approved by the Commission may be admitted conditionally to a Master’s program.  Such a student must meet the following requirements during the period of conditional admission or be subject to dismissal:

  1. a.     must achieve a TOEFL score of 550, or equivalent, by the end of the student’s first semester of study;
  2. b.     may take a maximum of six credit hours in the first semester of study, not including intensive English courses;
  3. c.     must achieve an overall grade point average of 3.00 on a 4.0 scale, or its established equivalent, in the first nine credit hours of credit-bearing courses studied for the Master’s program.
 
(2)    Conditional admission due to non fulfillment of GPA requirement:

A student with a recognized baccalaureate degree with a cumulative grade point average below 3.00 on a 4.0 scale, or its established equivalent, and who meets the English language competency requirements for general admission stated in Part I above, may be admitted conditionally to a Master’s program.  Such a student must  meet the following requirements during the period of conditional admission or be subject to dismissal:

  1. a.     may take a maximum of nine credit hours in the first semester of study;
  2. b.     must achieve an overall grade point average of 3.00 on a 4.0 scale, or its established equivalent, in the first nine credit hours of credit-bearing courses studied for the Master’s program.
 

ii-c: English Proficiency Requirements:

A TOEFL score of 550, IELTS of 6, or the equivalent of another standardized test approved by MHESR, is required for all students admitted to the MScPharm program with the following exceptions:

  • A  native  speaker  of  English  who  has  completed  his/her  undergraduate education in an English medium institution in a country where English is the official language.
  • A student admitted to and graduated from an English medium institution that can provide evidence of acquiring a TOEFL score of 500, or its standardized equivalent approved by the MHESR, upon admission to the undergraduate program.
 

iii. Transfer Admissions Policy

  1. Only students transferring from a federal of licensed institutions in the UAE or recognized foreign institutions of higher learning are eligible for admission.
  2. An officially attested BPharm degree, earned in a discipline appropriate for the prospective graduate degree.
  3. Transfer students must meet the English language proficiency requirement of the program to which they transfer.
  4. Official transcripts of credit earned from all institutions of higher education previously attended.
  5. Students who are in a good academic standing (a minimum cumulative grade point average of 3.0 on a 4.0. scale, or equivalent) can transfer to a graduate program of study similar to that which the student is transferring.
  6. Transfer graduate students program credits only for courses relevant to the degree that provide equivalent learning outcomes and in which the student earned a grade of B (3.0 on a 4.0 scale) or better.
  7. The applicant will be informed for transfer admissions or re-admission of the transfer credits earned for previous courses.
  8. Transfer of credit hours is limited to less than 50% of the total credit hours required for the program.
  9. AUST does not grant credit twice for substantially the same course taken at two different institutions.

Course Description

701601 Clinical Pharmacokinetics (2-2-3)

This course is designed to provide students with various important aspects of basic concepts & principles of pharmacokinetics with special emphasis on clinical applications. The course shall focus on the application of compartmental & non-compartmental models to determine various pharmacokinetic parameters including; absorption, distribution, apparent volume of distribution and elimination, following single and multiple IV and oral doses. The course shall provide students with concepts of non-linear pharmacokinetic models and their clinical applications. Principles of clinical pharmacokinetics will be thoroughly covered with special emphasis on pharmacokinetic and pharmacogenomics variability, therapeutic drug monitoring, individualization of drug therapy, kinetics of drug interaction and pharmacokinetic approach to new drug discovery.

Pre-requisites: Biopharmaceutics and Pharmacokinetics I and II (700311 & 700312)

701602 Novel Drug Delivery Systems (2-0-2)

The development of novel drug delivery systems has improved the efficacy and safety of many important therapeutic agents. Understanding the release characteristics of drugs from these dosage forms is essential for their optimal use.

This course is designed to cover basic principles & concepts of controlled release drug delivery systems including extended release, delayed release & targeted release drug products for oral, trans-mucosal, trans-dermal, intra-ocular, intra-vaginal, intra-uterine & parenteral administration. The course includes potential advantages & limitations as well as drugs candidates for oral controlled release drug products. The course will also describe advanced concepts applied in the design, formulation & development of controlled release products; including principle of design, excipients used, biopharmaceutical factors influencing design strategy, dosage form selection & drug release mechanisms. In addition, the course will describe the concept of drug targeting & its therapeutic importance.

The course shall also discuss various biopharmaceutical, pharmacokinetic & clinical aspects of controlled release products as well as official in-vivo & in-vitro tests used to evaluate controlled release drug delivery systems. The course will also cover liposomes as potential tools for drug delivery.

Pre-requisite: Clinical Pharmacokinetics (701601)

701603 Applied Instrumental Analysis (2-0-2)

The course presents a comprehensive overview of the field of instrumental analysis as practiced today. The course reviews the major methods available covering the basic principles, advantages and disadvantages, limitations and applicability of each method.

The course will introduce the students to the current instrumental methods of analysis and to cultivate sound experimental techniques covering electrochemical methods, absorption and emission spectroscopy UV-Vis spectrophotometery, fluorimetry and phosphometry , AJMAN UNIVERSITY OF SCIENCE AND TECHNOLOGY 113

atomic emission spectroscopy Raman spectroscopy, X ray methods, radiochemical methods chromatographic methods, NMR, IR and mass spectrometry

Pre-requisites: Instrumental Analysis I & II (700422 & 700425)

701605 Complementary Medicine (2-0-2)

In this course the student is acknowledged of the various types of Medicine which are practiced nowadays, and the main differences between these types with more emphasis on Complementary and Alternative Medicine ( CAM ).

In this course CAM is classified into SIX Systems, based on different philosophies :

1- Alternative Medical Systems. 2-Mind-Body System. 3- Biological-Based System. 4- Manipulative Body-Based System 5- Energy System. 6- Blood Cupping. This in addition to Iridology as a diagnostic technique.

Each of these systems include different Therapies which are instructed in details, including definition, philosophy, techniques, indications, and contraindications for each therapy.

Pre-requisite: Phytochemistry (700321)

701606 Pathophysiology & Pharmacotherapy I (2-0-2)

The course deals with a compressive over view in the field of Pharmacology and therapeutics as commonly practice today. The course covering:

1- The study in depth the mechanism of action of drugs that mimic or antagonize the sympathetic, parasympathetic nervous systems and neuromuscular junction. Concepts of receptor activation and neurohumoral transmission will be discussed.

2- Advanced knowledge in pharmacological aspects and therapeutic applications of drugs acting on cardiovascular, urinary, heamatologic, respiratory, gastrointestinal systems. It gives emphasis on molecular pharmacology of these drugs as well as aspects of clinical usefulness such as contraindications, interactions and unwanted effects. Also the concept of nitric oxide.

3- Detailed neuropharmacological aspects and therapeutic uses with emphasis on biochemical defects underlying the diseases of the new drugs used in treatment of neurological, behavior disorders. Also drugs for inflammatory and related disorders will also be discussed.

4- The rationale for the choice of certain drugs in the treatment of specified disease states. More emphasis will directed towards the mechanism of action, adverse effects and contraindications of chosen drugs. Use drugs in special cases such as pregnancy, lactation, elderly patients will be discussed.

5- Various toxicological aspects of the most commonly used drugs and toxic agents. Also its potential abuse and addiction will be discussed.

6- Rational drug use and misuse of antibiotics.

 

Pre-requisites: Clinical Pharmacy I & II (700442 & 700443)

701607 Pharmaceutical Care (2-1-3)

The graduates will be equipped with knowledge, skills, and practice capabilities to perform a clinical evaluation of the usage of medications in the hospital, also evaluation of drug GRADUATE STUDENT CATALOG 114

safety and efficacy, evaluation of prescribing habits. This subject will establish the knowledge of medical research, expose students to different types of studies including descriptive and comparative, observational and interventional.

Pre-requisites: Pathophysiology & Pharmacotherapy (701606)

701608 Pathophysiology and pharmacotherapy – II (2-0-2)

Pharmacotherapy is a crucial part of medicines management (or pharmaceutical care) for patients. This pharmacotherapy course starts with the introduction to pharmacotherapy, clinical calculations, pharmacokinetics and diagnostic tests and procedures in each of the selected diseases. The disease processes in common clinical conditions will be studied, including introduction to relevant pathology, the rationale underlying the management of these conditions and the choice of drug therapy for individual patients.

Pre-requisites: Pathophysiology & Pharmacotherapy I (701606)

701609 Clinical Biochemistry (1-1-2)

1. Advanced enzyme kinetics and regulation of enzyme activities. Applied enzymology. Immobilized enzymes. Enzyme mechanism. Biotransformation.

2. Fundamental Aspects of structure-function relationships of proteins and overall coverage of intermediary metabolism. Protein Folding. Protein Engineering. Plasma Proteins and immunoglobulins. Homeostasis and thrombosis. Intracellular Traffic and Sorting of Proteins. The Extracelluler matrix.

3. The Diversity of the Endocrine system. Hormones, structure & function of biomicromoleculer Hormone Action & Signal Transduction.

4. Drug Metabolism. Drug Discovery. Antibiotics. Biomedical Biochemistry Receptors

 

Pre-requisites: Biochemistry I & II ( 700231 & 700232)

701610 Clinical Microbiology (2-0-2)

Clinical Microbiology is an important part of drug management for patients with infectious diseases. This course focuses on pathophysiology of infectious diseases, diagnosis, management, prevention and control. The course is primarily intended to provide a firm ground in the understanding of infectious diseases, its management and control.

Pre-requisite: Clinical Biochemistry (701609)

701611 Research Thesis (0-6-6)

The thesis forms an extremely important component of the MSc Program since it will bring together many aspects of the skills and knowledge acquired during the study period. Each student will undertake an individual project on a topic related to the concentration area of his study. Topics investigated may be chosen by the student or suggested by the faculty. The area of research should be approved by the supervising faculty before commencement of the project. The research need not be on an original topic but should increase knowledge in the chosen area. It must be conducted according to the accepted AJMAN UNIVERSITY OF SCIENCE AND TECHNOLOGY 115

methods of scientific investigation, and be presented bound in the standard university format, by the end of the course.

Pre-requisite: Completion of 26 C.H.

701612 Advances in Pharmaceutical Technology (2-0-2)

This course is designed to provide students with various important aspects of process validation and CGMP; including regulatory and quality compliance as applied to the pharmaceutical industries. Upon completion, students will have acquired an in-depth knowledge in the organization and operation of the major departments of pharmaceutical companies, as well as ways of dealing with regulatory and compliance issues. Additionally, the course will provide background information on the drug development process from discovery to the marketplace. Other essential topics in advanced pharmaceutical technology will also be covered; including production management, production planning, production capacities, production organization, economic policy, manufacturing economics and production lines. In addition, various designing criteria needed to manufacture some sterile and non-sterile products shall also be discussed. The course will also include process automation in pharmaceutical manufacturing, pilot plant and scale up techniques as well as the design and development of packaging units including recent advances in packaging techniques.

Pre-requisite: Clinical Pharmacokinetics (701601)

701613 Products of Biotechnology (2-0-2)

This course is designed to acquaint students with the field of biotechnology. Topics will include a history of biotechnology, the drug discovery and development processes, and a description of current biotechnology products. Biotechnological techniques, such as cloning of DNA, expression of cloned DNA, manipulation of DNA sequence information, new biological targets for drug development, novel drug screening strategies, novel biological agents, antibodies, antisense, oligo-nucleotide therapy and gene therapy will be thoroughly covered. The course also entails the different methods adopted for preparation of biotechnology products and their evaluation, handling and storage. Issues that impact both the industry and the general population, such as stem cell research and bioethics shall be discussed as part of other topics introduced in the course. In addition, future prospects for new biotechnology products shall be discussed.

Pre-requisite: Clinical Biochemistry (701609) GRADUATE STUDENT CATALOG 116

701614 Chemistry of Heterocycles (2-0-2)

This course deals with the application of structure and theory to the study of organic heterocyclic compounds and their nomenclature, preparation and reaction mechanisms.

Pre-requisites: Pharmaceutical Medicinal Chemistry I & II (700323 & 700324)

701615 Chemistry of Natural Products (1-0-1)

Chemistry of Natural Products is a college elective course. It deals with the historical and contemporary role of secondary natural products in health care and commerce.

The course covers the classification of natural products according to their biosynthetic origins and chemical properties. A special emphasis will be placed on how chemical structure affects the physiological function of various natural products. These "structure activity relationships" help us learn about the interaction of small molecules in living systems and pharmacology of drugs.

Pre-requisite: Phytochemistry (700321)

701616 Application of Radiopharmaceuticals (1-1-2)

This course covers the fundamentals of nuclear pharmacy, radiopharmaceuticals compounding, stability prediction, packaging as well as uses and applications of radiopharmaceuticals as a diagnostic and therapeutic agents. The nuclear pharmacy practice guideline of APHA Academy of Pharmacy Practice and Management (APHA-APPM) will be discussed to cover the responsibility of pharmacist in maintaining quality of radiopharma-ceuticals, safety of coworkers and environments and providing pharmaceutical care to patient with optimal outcome.

Pre-requisites: Pharmaceutical Medicinal Chemistry I & II (700323 & 700324)

701617 Pharmacoeconomics (2-0-2)

Basic and applied concepts of economic efficiency, pharmacoeconomics methods, and drug therapy outcome measures are presented with an emphasis on the practical application of such principles.

Pre-requisites: Clinical Pharmacy I & II (700442 & 700443), Research Methodology (701623)

Pharm. Legislation (700416)

701618 Medicine Management and Community Care (3-1-4)

The course offer students an insight into pharmacy and medicines management with the emphasis on evidence-based practice. Students will be introduced to the concepts of AJMAN UNIVERSITY OF SCIENCE AND TECHNOLOGY 117

pharmacy practice, pharmacoeconomics, risk assessment, health promotion and clinical governance. course comprises the following unit:

1. international pharmacy practice;

2. Evidence based medicine and critical appraisal

3. Clinical practice and formularies guidelines

4. Pharmacy management

5. Prescribing with the view of patient‟s age (elderly, paediatrics), patient‟s clinical situation (pregnancy, liver or renal disease) and morbidity or adverse drug reactions.

6. Public health and health promotion

 

Pre-requisites: Pharmaceutical Care (701607)

701619 Pharmacovigilance (2-0-2)

The monitoring of drug safety is becoming more important as the number of drugs on the market, drug usage, and number of recalls all increase. Furthermore, Post-marketing pharmacovigilance studies are needed to further define the safety profile of a drug product. For such purposes the pharmacovigilance was developed and promoted in the medical and pharmaceutical sciences. Pharmacovigilance is the science and activities relating to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. This course is designed to provide the students with an introduction to the fundamental elements of pre- and post-marketing pharmacovigilance. A good portion of the course will cover the medication safety as it related to the prescribing, dispensing and administration of all medications. The global harmonisation of pharmacovigilance data is also will be highlighted throughout the course. Teaching consists of lectures and workshop activities in small groups and takes into account real world situations. There are opportunities for sharing experiences and networking which contributes to the development of your knowledge and understanding of pharmacovigilance issues.

Pre-requisites: Clinical Pharmacokinetics (701601) and Pathophysiology and Pharmacotherpy I (701606)

701620 Drug Abuse (2-0-2)

This course provides an overview of the fundamental concepts in drug/substance abuse. The course contents will help to introduce participants to terminologies used in drug/substance abuse as well as their definitions. Participants will be provided with a comprehensive overview of the drugs of abuse that are most commonly used, in addition to their adverse effects on human health and society. Methods of treatment and client education will also be addressed. Laws and regulations concerning drug/substance abuse will be covered.

Pre-requisite: Pathophysiology and Pharmacotherapy I (701606)

701621 Practices in Complementary Medicine (2-0-2)

This course instructs the student on the necessary aspects required to acquire a full understanding knowledge on Herbal Medicine.

The course starts by the historical development of Herbal Medicine, its advantages, GRADUATE STUDENT CATALOG 118

drawbacks, and regulatory issues.

An advanced instruction on how medicinal plants work, their Pharmacodynamic effects, and Pharmacokinetic routes of their main active constituents is illustrated.

The major part of the course concentrates on full Monographs on Medicinal Plants used in Herbal Medicine. An approach to some clinical studies on medicinal plants followed by case discussion are presented in Tutorial classes. Some illustrations on Research and Development in the field of Medicinal Plants, are given.

Pre-requisite : Phytochemistry (700321)

701622 Biostatistics (2-0-2)

This course is comprised of lectures designed to aid the student to expand their knowledge in specific biostatistics relevant to the medical and pharmaceutical fields in addition to adequate knowledge of study design in medical and health research. This enables the student to critically evaluate pharmaceutical and medical research.

Pre-requisite: Statistics (30130)

701623 Research Methodology (2-0-2)

The course includes the following topics: the thinking process and manner of establishing human knowledge, science and scientific method, the research process, types of research methodologies pertinent to different fields of knowledge, steps of performing research from the first step of defining the research problem until the final step of writing the research article or report.

The course involves studying samples selection, data collection, data processing and data displaying. Finally, the course stresses upon case studies extracted from the pharmaceutical and other fields and we end up the course with ethical considerations involved in the field of pharmacy.

Pre-requisite: Statistics (30130)